Otorhinolaryngologic Manifestations of Wegener's Granulomatosis

ENT manifestations of Wegeners granulomatosis.

Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...

Otorhinolaryngologic Manifestations in Leishmaniasis

Neutrophil chemotaxis in Wegeners granulomatosis and idiopathic pulmonary fibrosis

Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener’s granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...

Gingival manifestations of orofacial granulomatosis.

BACKGROUND Orofacial granulomatosis is a clinical entity presenting with swelling of the facial and/or oral tissues in association with histologic evidence of noncaseating granulomatous inflammation. Labial swelling is the most common finding. Compromise of the gingival and periodontal tissues may occur but has rarely been described in the literature. Our objective was to characterize granuloma...

Clinical manifestations and prognosis of Wegener's granulomatosis.

reported. In contrast, we recently reported a case of WGin whomthe first clinical manifestation was acute renal failure due to periglomerular granulomatosis with crescentic glomerulonephritis and the late development of respiratory lesion. The case could be a "delayed variant" or limited form of WG localized in the kidney (1). Accordingly, the combination of organ involvement is not sufficient ...